USC. Use of Quorum Quenching enzymes as oral biofilm formation inhibitors

USC. Use of Quorum Quenching enzymes as oral biofilm formation inhibitors[line_break]ES2342807B2 y ES2528673B1

Project Description

The USC research group offers two patents in the field of the Use of Quorum Quenching enzymes as inhibitors of oral biofilm formation. These are shown below:

1. Use of bacteria of the genus Tenacibaculum for quenching (ES2342807B2; EP2356991B1; US8586343B2; CN102149395B)
2. Peptide with quorum inhibitory activity, a polynucleotide that encodes this peptide, and its uses (ES2528673B1; EP3020814A1; US2016244735A1)

It is proposed to use an enzyme or cell extract obtained from a marine bacterium within the genus Tenacibaculum (Tenacibaculum sp. strain 20J) that interferes with these QS signals (known as “”quorum quenching”” (QQ) through enzymatic degradation of AHL molecules, to inhibit biofilm formation and to control bacterial infections. In addition, QQ was discovered against the AI-2 QS signal in the cell extract of the 20J strain, extending the range of applications of this strain to Gram-positive pathogens.

You can consult the patent description sheet.

Description of the Area of Activity / Technology

The use of this strain and the derived enzyme to block processes controlled by LFA-mediated quorum detection, specifically the formation of biofilms by Gram-negative pathogens or in mixed biofilms where Gram-negative bacteria are present. On the other hand, the use of this strain serves to block those controlled by the AI-2 QS signal, and more specifically, those involving oral streptococci.

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